At Homeostasis Filarial Infections Have Expanded Adaptive T Regulatory but Not Classical Th2 Cells
Identifieur interne : 005A15 ( Main/Exploration ); précédent : 005A14; suivant : 005A16At Homeostasis Filarial Infections Have Expanded Adaptive T Regulatory but Not Classical Th2 Cells
Auteurs : Simon Metenou [États-Unis] ; Benoit Dembele [Mali] ; Siaka Konate [Mali] ; Housseini Dolo [Mali] ; Siaka Y. Coulibaly [Mali] ; Yaya I. Coulibaly [Mali] ; Abdallah A. Diallo [Mali] ; Lamine Soumaoro [Mali] ; Michel E. Coulibaly [Mali] ; Dramane Sanogo [Mali] ; Salif S. Doumbia [Mali] ; Sekou F. Traoré [Mali] ; Siddhartha Mahanty [États-Unis] ; Amy Klion [États-Unis] ; Thomas B. Nutman [États-Unis]Source :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2010.
Descripteurs français
- KwdFr :
- Animaux, Cytokines (biosynthèse), Enterobius (immunologie), Filariose lymphatique (immunologie), Homéostasie (immunologie), Humains, Hymenolepis nana (immunologie), Hyménolépiase (immunologie), Immunité acquise, Lymphocytes T régulateurs (immunologie), Lymphocytes T régulateurs (métabolisme), Lymphocytes T régulateurs (parasitologie), Lymphocytes auxiliaires Th2 (immunologie), Lymphocytes auxiliaires Th2 (métabolisme), Lymphocytes auxiliaires Th2 (parasitologie), Mansonella (immunologie), Mansonellose (immunologie), Microfilaria (immunologie), Oxyurose (immunologie), Wuchereria bancrofti (immunologie).
- MESH :
- biosynthèse : Cytokines.
- immunologie : Enterobius, Filariose lymphatique, Homéostasie, Hymenolepis nana, Hyménolépiase, Lymphocytes T régulateurs, Lymphocytes auxiliaires Th2, Mansonella, Mansonellose, Microfilaria, Oxyurose, Wuchereria bancrofti.
- métabolisme : Lymphocytes T régulateurs, Lymphocytes auxiliaires Th2.
- parasitologie : Lymphocytes T régulateurs, Lymphocytes auxiliaires Th2.
- Animaux, Humains, Immunité acquise.
English descriptors
- KwdEn :
- Adaptive Immunity, Animals, Cytokines (biosynthesis), Elephantiasis, Filarial (immunology), Enterobiasis (immunology), Enterobius (immunology), Homeostasis (immunology), Humans, Hymenolepiasis (immunology), Hymenolepis nana (immunology), Mansonella (immunology), Mansonelliasis (immunology), Microfilariae (immunology), T-Lymphocytes, Regulatory (immunology), T-Lymphocytes, Regulatory (metabolism), T-Lymphocytes, Regulatory (parasitology), Th2 Cells (immunology), Th2 Cells (metabolism), Th2 Cells (parasitology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , biosynthesis : Cytokines.
- immunology : Elephantiasis, Filarial, Enterobiasis, Enterobius, Homeostasis, Hymenolepiasis, Hymenolepis nana, Mansonella, Mansonelliasis, Microfilariae, T-Lymphocytes, Regulatory, Th2 Cells, Wuchereria bancrofti.
- metabolism : T-Lymphocytes, Regulatory, Th2 Cells.
- parasitology : T-Lymphocytes, Regulatory, Th2 Cells.
- Adaptive Immunity, Animals, Humans.
Abstract
Despite the well-documented immune suppression associated with human helminth infections, studies characterizing the immune response at the single-cell level are scanty. We used multiparameter flow cytometry to characterize the type of effector (Th1, Th2, and Th17) and regulatory (natural T regulatory cells [nTregs] and adaptive Treg cells [aTreg/type 1 regulatory cells (Tr1s)]) CD4+ and CD8+ T cells in filaria-infected (Fil+) and -uninfected (Fil−) individuals at homeostasis (in the absence of stimulation). Frequencies of CD4+ lymphocytes spontaneously producing IL-4, IL-10, and IL-17A were significantly higher in Fil+, as were those of IL-10+/IL-4+ double-producing CD4+ cells. Interestingly, frequencies of Th17 and aTreg/Tr1s but not classical Th1 or Th2 cells were significantly increased in Fil+ compared to Fil− individuals. Although the frequency of nTreg was increased in Fil+, IL-10 was overwhelmingly produced by CD4+CD25− cells. Moreover, the concentration of IL-10 produced spontaneously in vitro strongly correlated with the integrated geometric mean fluorescence intensity of IL-10–producing aTreg/Tr1s in Fil+. Together, these data show that at steady state, IL-10–producing aTreg/Tr1 as well as nTreg and effector Th17 CD4+ cells are expanded in vivo in human filarial infections. Moreover, we have established baseline ex vivo frequencies of effector and Tregs at homeostasis at a population level.
Url:
DOI: 10.4049/jimmunol.0904067
PubMed: 20357251
PubMed Central: 3407820
Affiliations:
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Le document en format XML
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</affiliation>
</author>
<author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title>
<idno type="ISSN">0022-1767</idno>
<idno type="eISSN">1550-6606</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptive Immunity</term>
<term>Animals</term>
<term>Cytokines (biosynthesis)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Enterobiasis (immunology)</term>
<term>Enterobius (immunology)</term>
<term>Homeostasis (immunology)</term>
<term>Humans</term>
<term>Hymenolepiasis (immunology)</term>
<term>Hymenolepis nana (immunology)</term>
<term>Mansonella (immunology)</term>
<term>Mansonelliasis (immunology)</term>
<term>Microfilariae (immunology)</term>
<term>T-Lymphocytes, Regulatory (immunology)</term>
<term>T-Lymphocytes, Regulatory (metabolism)</term>
<term>T-Lymphocytes, Regulatory (parasitology)</term>
<term>Th2 Cells (immunology)</term>
<term>Th2 Cells (metabolism)</term>
<term>Th2 Cells (parasitology)</term>
<term>Wuchereria bancrofti (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cytokines (biosynthèse)</term>
<term>Enterobius (immunologie)</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Homéostasie (immunologie)</term>
<term>Humains</term>
<term>Hymenolepis nana (immunologie)</term>
<term>Hyménolépiase (immunologie)</term>
<term>Immunité acquise</term>
<term>Lymphocytes T régulateurs (immunologie)</term>
<term>Lymphocytes T régulateurs (métabolisme)</term>
<term>Lymphocytes T régulateurs (parasitologie)</term>
<term>Lymphocytes auxiliaires Th2 (immunologie)</term>
<term>Lymphocytes auxiliaires Th2 (métabolisme)</term>
<term>Lymphocytes auxiliaires Th2 (parasitologie)</term>
<term>Mansonella (immunologie)</term>
<term>Mansonellose (immunologie)</term>
<term>Microfilaria (immunologie)</term>
<term>Oxyurose (immunologie)</term>
<term>Wuchereria bancrofti (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Enterobius</term>
<term>Filariose lymphatique</term>
<term>Homéostasie</term>
<term>Hymenolepis nana</term>
<term>Hyménolépiase</term>
<term>Lymphocytes T régulateurs</term>
<term>Lymphocytes auxiliaires Th2</term>
<term>Mansonella</term>
<term>Mansonellose</term>
<term>Microfilaria</term>
<term>Oxyurose</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term>
<term>Enterobiasis</term>
<term>Enterobius</term>
<term>Homeostasis</term>
<term>Hymenolepiasis</term>
<term>Hymenolepis nana</term>
<term>Mansonella</term>
<term>Mansonelliasis</term>
<term>Microfilariae</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Th2 Cells</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>T-Lymphocytes, Regulatory</term>
<term>Th2 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphocytes T régulateurs</term>
<term>Lymphocytes auxiliaires Th2</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Lymphocytes T régulateurs</term>
<term>Lymphocytes auxiliaires Th2</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>T-Lymphocytes, Regulatory</term>
<term>Th2 Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adaptive Immunity</term>
<term>Animals</term>
<term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Humains</term>
<term>Immunité acquise</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Despite the well-documented immune suppression associated with human helminth infections, studies characterizing the immune response at the single-cell level are scanty. We used multiparameter flow cytometry to characterize the type of effector (Th1, Th2, and Th17) and regulatory (natural T regulatory cells [nTregs] and adaptive Treg cells [aTreg/type 1 regulatory cells (Tr1s)]) CD4<sup>+</sup>
and CD8<sup>+</sup>
T cells in filaria-infected (Fil<sup>+</sup>
) and -uninfected (Fil<sup>−</sup>
) individuals at homeostasis (in the absence of stimulation). Frequencies of CD4<sup>+</sup>
lymphocytes spontaneously producing IL-4, IL-10, and IL-17A were significantly higher in Fil<sup>+</sup>
, as were those of IL-10<sup>+</sup>
/IL-4<sup>+</sup>
double-producing CD4<sup>+</sup>
cells. Interestingly, frequencies of Th17 and aTreg/Tr1s but not classical Th1 or Th2 cells were significantly increased in Fil<sup>+</sup>
compared to Fil<sup>−</sup>
individuals. Although the frequency of nTreg was increased in Fil<sup>+</sup>
, IL-10 was overwhelmingly produced by CD4<sup>+</sup>
CD25<sup>−</sup>
cells. Moreover, the concentration of IL-10 produced spontaneously in vitro strongly correlated with the integrated geometric mean fluorescence intensity of IL-10–producing aTreg/Tr1s in Fil<sup>+</sup>
. Together, these data show that at steady state, IL-10–producing aTreg/Tr1 as well as nTreg and effector Th17 CD4<sup>+</sup>
cells are expanded in vivo in human filarial infections. Moreover, we have established baseline ex vivo frequencies of effector and Tregs at homeostasis at a population level.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Mali</li>
<li>États-Unis</li>
</country>
<region><li>Maryland</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Metenou, Simon" sort="Metenou, Simon" uniqKey="Metenou S" first="Simon" last="Metenou">Simon Metenou</name>
</region>
<name sortKey="Klion, Amy" sort="Klion, Amy" uniqKey="Klion A" first="Amy" last="Klion">Amy Klion</name>
<name sortKey="Mahanty, Siddhartha" sort="Mahanty, Siddhartha" uniqKey="Mahanty S" first="Siddhartha" last="Mahanty">Siddhartha Mahanty</name>
<name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name>
</country>
<country name="Mali"><noRegion><name sortKey="Dembele, Benoit" sort="Dembele, Benoit" uniqKey="Dembele B" first="Benoit" last="Dembele">Benoit Dembele</name>
</noRegion>
<name sortKey="Coulibaly, Michel E" sort="Coulibaly, Michel E" uniqKey="Coulibaly M" first="Michel E." last="Coulibaly">Michel E. Coulibaly</name>
<name sortKey="Coulibaly, Siaka Y" sort="Coulibaly, Siaka Y" uniqKey="Coulibaly S" first="Siaka Y." last="Coulibaly">Siaka Y. Coulibaly</name>
<name sortKey="Coulibaly, Yaya I" sort="Coulibaly, Yaya I" uniqKey="Coulibaly Y" first="Yaya I." last="Coulibaly">Yaya I. Coulibaly</name>
<name sortKey="Diallo, Abdallah A" sort="Diallo, Abdallah A" uniqKey="Diallo A" first="Abdallah A." last="Diallo">Abdallah A. Diallo</name>
<name sortKey="Dolo, Housseini" sort="Dolo, Housseini" uniqKey="Dolo H" first="Housseini" last="Dolo">Housseini Dolo</name>
<name sortKey="Doumbia, Salif S" sort="Doumbia, Salif S" uniqKey="Doumbia S" first="Salif S." last="Doumbia">Salif S. Doumbia</name>
<name sortKey="Konate, Siaka" sort="Konate, Siaka" uniqKey="Konate S" first="Siaka" last="Konate">Siaka Konate</name>
<name sortKey="Sanogo, Dramane" sort="Sanogo, Dramane" uniqKey="Sanogo D" first="Dramane" last="Sanogo">Dramane Sanogo</name>
<name sortKey="Soumaoro, Lamine" sort="Soumaoro, Lamine" uniqKey="Soumaoro L" first="Lamine" last="Soumaoro">Lamine Soumaoro</name>
<name sortKey="Traore, Sekou F" sort="Traore, Sekou F" uniqKey="Traore S" first="Sekou F." last="Traoré">Sekou F. Traoré</name>
</country>
</tree>
</affiliations>
</record>
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